J Biomed 2017; 2:34-38. doi:10.7150/jbm.17794 This volume Cite
Short Research Communication
Correlation Pattern of Serum Lipid Parameters and a Biological Anti-Oxidant Potential Between Premenopausal and Perimenopausal Healthy Women
1. Jui-Tung Chen Clinic, Tokyo, Japan,
2. Division of Community and Family Medicine, Jichi Medical University, Tochigi, Japan
Objectives. Improved understanding of the associations among cardiometabolic, antioxidative, and menopausal status is crucial to prevent cardiovascular disease (CVD). For preventing the development of CVD in women, the association of serum lipid profile and antioxidant parameters during menopausal transition is of interest. The aim of the study is to evaluate the correlation between lipid and antioxidant levels especially in premenopausal and perimenopausal women.
Methods. A total of 130 CVD-free healthy women; the premenopausal group (n = 51, mean 41 years) and perimenopausal group (n = 79, mean 49 years) were studied. A biological antioxidant potential (BAP) test was utilized for measuring antioxidant levels. The association between lipid and BAP levels was examined by linear correlation analyses.
Results. The perimenopausal group showed a significantly higher low-density lipoprotein cholesterol (LDL-C) level than the premenopausal group (mean 123 vs. 111 mg/dL, p < 0.05), while there were no significant differences in triglyceride, high-density lipoprotein cholesterol and BAP levels between the groups. A significant inverse correlation existed between LDL-C and BAP levels in the perimenopausal group (β = -0.30, p < 0.05), but not in the premenopausal group.
Conclusions. The correlation patterns between lipid parameters and antioxidant levels demarcated the premenopausal from perimenopausal stage. Increased LDL-C associated with decreased antioxidant levels in perimenopausal women may call early attention for cardiovascular health.
Keywords: antioxidants, estrogen, FSH, LDL cholesterol, perimenopause