J Biomed 2016; 1:1-4. doi:10.7150/jbm.16497

Research Paper

Dietary Intake of Vitamin D Is Related to Blood Levels of Advanced Glycation End Products during a Weight Loss Program in Obese Women

Shin Sukino1, Kazuhiko Kotani1,2,3, Shinsuke Nirengi1, Alejandro Gugliucci3, Russell Caccavello3, Kokoro Tsuzaki1, Yaeko Kawaguchi1, Kaoru Takahashi4, Kahori Egawa5, Hiroshi Shibata5, Makiko Yoshimura6, Yoshinori Kitagawa7, Naoki Sakane1✉

1. Division of Preventive Medicine, National Hospital Organization Kyoto Medical Center, Kyoto, Japan;
2. Division of Community and Family Medicine, Jichi Medical University, Shimotsuke-City, Tochigi, Japan;
3. Glycation, Oxidation and Disease Laboratory, Touro University-California, CA, USA;
4. Hyogo Health Service Association;
5. Institute for Health Care Science, Health Care Science Center, Suntory Wellness Limited, Kyoto, Japan;
6. HE Center, R&D Support Division, Suntory Business Expert Limited, Kyoto, Japan;
7. Safety Science Institute, Quality Assurance Division, Suntory Business Expert Limited, Kyoto, Japan.

Abstract

BACKGROUND/OBJECTIVES: Advanced glycation end products (AGEs) contribute to the pathophysiology of lifestyle-related diseases. To identify nutrients associated with AGEs, this study explored the factors by investigating the relationship between nutrients changes and changes of blood AGEs during a weight loss program in obese women.

SUBJECTS/METHODS: Twenty-five obese women (age: 50 ± 8 years, body mass index: 28.7 ± 3.4 kg/m2) underwent a weight loss program with energy-restricted meal replacement for 2 months. Three-day weighted dietary records and blood tests including blood AGEs were performed at the baseline and after the 2-month intervention. Their correlation was examined during the intervention period.

RESULTS: The changes in AGEs were significantly and negatively correlated with those of intake levels of vitamin D (r = -0.54; P < 0.05).

CONCLUSION: Vitamin D might be a useful nutrient to reduce AGEs in obese women.

Keywords: AGEs, weight loss, vitamin D.

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How to cite this article:
Sukino S, Kotani K, Nirengi S, Gugliucci A, Caccavello R, Tsuzaki K, Kawaguchi Y, Takahashi K, Egawa K, Shibata H, Yoshimura M, Kitagawa Y, Sakane N. Dietary Intake of Vitamin D Is Related to Blood Levels of Advanced Glycation End Products during a Weight Loss Program in Obese Women. J Biomed 2016; 1:1-4. doi:10.7150/jbm.16497. Available from http://www.jbiomed.com/v01p0001.htm